Copperplate
Systematic review & meta-analysis

Systematic Review Help and Meta-Analysis Services, From Protocol to PRISMA

Systematic review help at every stage: protocol and PROSPERO registration, database searches, screening, risk of bias, meta-analysis and GRADE. We consult, check and coach, so your review meets PRISMA 2020 and you can defend each methodological choice.

  • PROSPERO protocols and PRISMA 2020 reporting
  • RoB 2, ROBINS-I and Newcastle-Ottawa
  • Meta-analysis in R metafor or RevMan
Sample edit — Public health (meta-analysis results)

A random-effects meta-analysis of 14 trials showed that exercise reduced HbA1c (MD = −0.48%, 95% CI [−0.66, −0.30]; 95% PI [−1.09, 0.13]). Heterogeneity was substantial (I² = 71%, τ² = 0.07), and certainty was rated moderate using GRADE.

Live example

What systematic review help covers

A systematic review answers a focused question by searching, selecting and appraising all eligible studies using a pre-specified, reproducible method, and a meta-analysis statistically pools their results where studies are similar enough. Our systematic review help is methodological consulting and coaching: you lead the review, and we check, explain and run analyses with you.

You can book support for one stage or the whole review:

  • Protocol writing, PICO or PECO framing and PROSPERO registration
  • Search strategies for PubMed, Embase, Scopus, Web of Science and CINAHL
  • Screening workflows in Covidence or Rayyan
  • Data extraction forms, risk of bias and critical appraisal
  • Meta-analysis, sensitivity analyses and GRADE certainty ratings
  • PRISMA 2020 reporting and peer-review responses

Many clients start with our working sessions as a systematic review tutor, then ask us to check the finished manuscript.

Protocol, PROSPERO registration and search strategies

Ask a librarian to peer review your search with the PRESS checklist. Reviewers notice when a search has never been tested.

We review your protocol against PRISMA-P and help you complete the PROSPERO form. PROSPERO registers reviews with a health-related outcome and expects registration before data extraction starts; it does not accept scoping reviews, which can be registered on OSF instead.

Search strategies combine controlled vocabulary with free-text terms, joined by Boolean operators: OR within a concept, AND between concepts. We check MeSH selection and explosion, truncation, phrase searching and field tags, then translate the strategy across databases.

PubMed search block

("Diabetes Mellitus, Type 2"[Mesh] OR "type 2 diabetes"[tiab] OR T2DM[tiab]) AND ("Exercise"[Mesh] OR exercis*[tiab] OR "physical activity"[tiab]) AND (randomized controlled trial[pt] OR randomi*[tiab])

In Scopus the free-text lines move into TITLE-ABS-KEY(); in Web of Science they move into TS=(). Neither database uses MeSH, so the free-text side must carry more weight.

We also check that the search is reported to the PRISMA-S extension, with full strategies for every database in a supplement.

Systematic Review & Meta-Analysis Support

Send your file today and get a quote with a matched editor.

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Systematic review software for screening and extraction

Screening should be done by two independent reviewers at title and abstract stage and again at full text, with conflicts resolved by discussion or a third reviewer. The right software makes that audit trail easy to report.

ToolBest suited toNotes
CovidenceDual screening, full-text review and extraction in one placeSubscription; many universities hold a license
RayyanFast title and abstract screening with blindingFree tier available; paid plans add features
DistillerSRLarge or regulated reviews with custom formsCommercial; strong audit trail
EndNote or ZoteroDeduplication before screeningRecord the number of duplicates removed

We help you pilot eligibility criteria on a sample, calculate agreement between screeners and design extraction forms that capture exactly what your analysis needs.

PRISMA 2020 flow diagram and checklist

The PRISMA 2020 statement has a 27-item checklist, a 12-item checklist for abstracts and updated flow diagram templates. We check every item against your manuscript and build the flow diagram from your screening records.

The 2020 diagram separates three units that are often confused:

  • Records: titles and abstracts retrieved from databases and registers.
  • Reports: full-text documents sought, retrieved and assessed for eligibility, with exclusion reasons.
  • Studies: the investigations included, since one study can have several reports.

Numbers must reconcile from identification to inclusion. For a step-by-step walkthrough, read our PRISMA flow diagram guide.

Risk of bias and critical appraisal tools

ToolStudy designStructure and judgments
RoB 2Randomized trialsFive domains, from the randomization process to selection of the reported result; low risk, some concerns or high risk
ROBINS-INon-randomized studies of interventionsSeven domains, including confounding and selection of participants; low, moderate, serious or critical risk
Newcastle-Ottawa ScaleCohort and case-control studiesSelection, comparability, and outcome or exposure; star-based rating
CASP or JBI checklistsQualitative and other designsStructured appraisal questions

We check that judgments are made per outcome where the tool requires it, that each one is supported by quoted evidence from the study, and that results feed into your synthesis. We can produce traffic-light and summary plots with the robvis package in R.

Meta-analysis software: R metafor, RevMan and CMA

We run and check meta-analyses with you in R using metafor, or in RevMan. A typical metafor workflow computes effect sizes with escalc(), fits a random-effects model with rma() (REML by default), and adds forest(), funnel() and regtest() for Egger’s test. We report τ², I² and a prediction interval, consider the Hartung-Knapp adjustment, and run leave-one-out and subgroup analyses that were pre-specified.

Funnel plot asymmetry tests are generally only meaningful with 10 or more studies, so we flag when they should not be reported. If you used Comprehensive Meta-Analysis (CMA), Stata or JASP, we can check and interpret your output. For Hunter and Schmidt psychometric meta-analysis, we use metafor’s HS estimator or the psychmeta package for artifact corrections. See also our R help service.

GRADE certainty of evidence

GRADE rates each outcome as high, moderate, low or very low certainty. Evidence is downgraded for risk of bias, inconsistency, indirectness, imprecision and publication bias, and can be upgraded for a large effect or a dose-response gradient. We help you build a Summary of Findings table with explicit footnotes for each decision.

How it works, and who does the review

  1. Send your protocol or draft, your stage and your deadline through the quote form.
  2. We match you with a methodologist who knows your field.
  3. You receive feedback in Track Changes with margin comments that explain the reasoning, plus annotated code and output for any analysis.
  4. You can ask follow-up questions about the comments after delivery.

Turnaround runs from 24 hours to 7 days depending on length. You keep full authorship. If one of our methodologists acts as a second screener or extractor, that contribution should be acknowledged as your journal requires. Check your institution’s rules and our academic integrity policy before you book.

Delivered to you

What you receive

  • Protocol and PROSPERO form feedback in Track Changes
  • Search strategies checked and translated across databases
  • PRISMA 2020 flow diagram and completed checklist review
  • Risk of bias tables and robvis plots
  • Annotated R metafor or RevMan analysis with forest and funnel plots
  • GRADE Summary of Findings table guidance
Who it’s for

Who we help

  • PhD candidates writing a systematic review chapter
  • Clinicians and public health researchers preparing a journal review
  • Master’s students completing a review-based dissertation
  • Authors revising a review after peer review
Process

How it works

  1. Send your file

    Upload your document and tell us the deadline, the style guide and what worries you most about the draft.

  2. Approve your quote

    We reply with a price, a delivery date and the editor matched to your field. Nothing starts until you agree.

  3. We edit and explain

    Your editor works in Track Changes and leaves margin comments that explain each important decision.

  4. Review and ask

    Accept what you agree with and ask your editor about any comment. The final choices are always yours.

FAQ

Questions about systematic review & meta-analysis support

Can you help me with my systematic review?

Yes. We support single stages, such as a search strategy or meta-analysis, or the whole process from protocol to submission. You lead the review and make the decisions; we check methods, explain options and run analyses with you so you can defend them in a viva or to reviewers.

What is the best systematic review software?

For most academic reviews, Covidence or Rayyan handles screening well, and the best choice is often whichever your university licenses. Rayyan has a free tier, which suits student projects. DistillerSR suits large or regulated reviews. For meta-analysis, R with metafor is free and flexible, and RevMan is standard for Cochrane-style reviews.

How do I cite Covidence systematic review software?

Covidence recommends this wording: Covidence systematic review software, Veritas Health Innovation, Melbourne, Australia. Available at www.covidence.org. Mention it in your methods where you describe screening and extraction. If your journal uses APA or Vancouver style, adapt the format but keep the developer, location and URL. Covidence has no version numbers, so use the year you did most of your screening.

Do I have to register my systematic review on PROSPERO?

Many journals and examiners expect registration for health-related reviews, and PROSPERO asks you to register before data extraction begins. Registration protects against selective reporting and shows your methods were planned. Scoping reviews are not accepted by PROSPERO; register them on OSF or publish the protocol in a journal.

Which meta-analysis software should I use?

R with metafor is free, transparent and handles almost every model. RevMan suits standard pairwise reviews, especially Cochrane ones. Comprehensive Meta-Analysis is commercial and menu-driven. Stata and JASP also run meta-analyses. Choose the tool whose output you can explain, and report the estimator and confidence interval method you used.

Can an AI tool do my meta-analysis?

Tools such as Rayyan and Covidence use machine learning to prioritize records for screening, which can save time. PRISMA 2020 asks you to report any automation tools used. Eligibility decisions, extraction and model choices still need human verification, and you remain responsible for every number in the paper.

How much does systematic review help cost?

Fees depend on the stages you need, the number of included studies and your deadline. See our pricing page, or send your protocol through the quote form for an exact quote.

Contact us

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Tell us your deadline and word count. You will hear back the same day with a quote and the editor matched to your field.

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